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Prenatal direct exposure to scarcity influences lifetime health

.Attributes Medication, Posted online: 09 September 2024 doi:10.1038/ d41591-024-00068-4Analysis of ...

An international metric of immune system wellness

.Attribute Medication, Posted online: 05 September 2024 doi:10.1038/ s41591-024-03210-4A study uses ...

Niacin, food intake and also heart results

.Attributes Medication, Released online: 05 September 2024 doi:10.1038/ s41591-024-03220-2Niacin, fo...

Opportunities as well as problems for patient-reported end result assessment in multimorbidity investigation and also practice

.Competing interests.S.E.H. gets funding coming from the National Principle of Health as well as Car...

Hibernation science took advantage of to handle weight problems as well as tweak metabolic rate

.Nature Medicine, Published online: 04 September 2024 doi:10.1038/ s41591-024-03226-wBy recognizing ...

CAR- T as well as cellular genetics therapies are actually as well pricey

.Nature Medicine, Posted online: 04 September 2024 doi:10.1038/ s41591-024-03231-zPoint-of-care prod...

The WHO genomics course of work with equitable application of individual genomics for worldwide health

.The magazine of the initial draft of the human genome pattern in 20011 was actually complied with d...

Advancing international antibiotic study, progression as well as access #.\n\nMurray, C. J. L. et al. Global concern of bacterial antimicrobial resistance in 2019: a systematic evaluation. Lancet 399, 629\u00e2 $ \"655 (2022 ). AMR Frontrunnerses. In the direction of details dedications as well as activity in the response to antimicrobial protection. Global Leaders Group on Antimicrobial Protection https:\/\/www.amrleaders.org\/resources\/m\/item\/glg-report (4 April 2024). Planet Health Association. WHO releases listing of bacteria for which new anti-biotics are quickly needed to have. Planet Wellness Association https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed (27 February 2017). Globe Health And Wellness Institution. That bacterial concern virus listing, 2024: microbial microorganisms of hygienics importance to help study, advancement and methods to prevent as well as manage antimicrobial protection. Globe Wellness Company https:\/\/www.who.int\/publications\/i\/item\/9789240093461 (17 May 2024). Silver, L. L. A Gestalt way to Gram-negative entrance. Bioorg. Medication. Chem. 24, 6379\u00e2 $ \"6389 (2016 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nSundqvist, M. Reversibility of antibiotic protection. Ups. J. Medication. Sci. 119, 142\u00e2 $ \"148 (2014 ).\nGoogle.com Scholar\u00c2.\nGlobe Health And Wellness Association. 2023 antibacterial brokers in clinical and preclinical growth: a summary and also evaluation. Globe Health and wellness Company https:\/\/www.who.int\/publications\/i\/item\/9789240094000 (14 June 2024). O' Neill, J. et cetera. AMR Customer review. May 19, 2016 \u00e2 $\" Dealing with drug-resistant infections internationally: ultimate record and also recommendations. Assessment on Antimicrobial Protection https:\/\/amr-review.org\/Publications.html (19 May 2016). Drive-AB Consortium. DRIVE-AB outputs: documents and instruction. Steer abdominal muscle https:\/\/drive-ab.eu\/drive-ab-outputs\/drive-ab-reports\/ (2016 ). Stern, S. et cetera. Breaking through the wall: a call for concurrent activity on antibiotics trial and error. Boston Consulting Group https:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/Dateien\/5_Publikationen\/Gesundheit\/Berichte\/GUARD_Follow_Up_Report_Full_Report_final.pdf (February, 2017). Anderson, M., Panteli, D. &amp Mossialos, E. Policy Short 51: How can the EU help sustainable technology and access to successful antibiotics? plan choices for existing and brand-new medicines. International Observatory on Health And Wellness Solutions and also Plans https:\/\/eurohealthobservatory.who.int\/publications\/i\/how-can-the-eu-support-sustainable-innovation-and-access-to-effective-antibiotics-policy-options-for-existing-and-new-medicines (21 June 2023). Turnidge, J. &amp Christiansen, K. Antibiotic use as well as resistance\u00e2 $\" showing the obvious. Lancet 365, 548\u00e2 $ \"549 (2005 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nPlanet Health And Wellness Association. 2021 AWaRe category. WHO accessibility, view, book, category of prescription antibiotics for assessment and also surveillance of utilization. Planet Health and wellness Company https:\/\/www.who.int\/publications\/i\/item\/2021-aware-classification (30 September 2021). International Center for Health Condition Deterrence and also Management. Antimicrobial resistance aim ats: just how can we reach all of them through 2030? ECDC https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/amr-brief-eaad-2023-update.pdf (2023 ). Globe Health And Wellness Association. Shortage of advancement readied to undermine antibiotic efficiency as well as health increases. Planet Health and wellness Company https:\/\/www.who.int\/news\/item\/22-06-2022-22-06-2022-lack-of-innovation-set-to-undermine-antibiotic-performance-and-health-gains (22 June 2022). Magnano San, L. R. et al. Exactly how antimicrobial resistance is linked to climate modification: an outline of 2 linked international challenges. Int. J. Environ. Res. Public Health 20, 1681 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nDolecek, C., Shakoor, S., Basnyat, B., Okwor, T. &amp Sartorius, B. Drug-resistant microbial infections: we need to have critical activity as well as assets that pay attention to the weakest link. PLoS Biol. 20, e3001903 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nPlanet Wellness Company. Booster shot insurance coverage. Planet Health Association https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/immunization-coverage (15 July 2024). Chimhini, G., Magwenzi, M. &amp Fitzgerald, F. C. Contamination avoidance and management in low-resource setups: the necessity for the neighborhood, the contextual and also the practical. Affect. Prev. Pract. 4, 100135 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nNour, S., Stokle, E., Ashiru-Oredope, D. &amp Wesangulae, E. Challenges of carrying out antimicrobial conservation devices in reduced to middle revenue nations (LMICs). Infect. Prev. Pract. 5, 100315 (2023 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nAminov, R. A quick past of the antibiotic era: courses knew and obstacles for the future. Front end. Microbiol. 1, 134 (2010 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nOutterson, K. et cetera. Patient accessibility in 14 high-income nations to brand new antibacterials approved due to the US Food and Drug Administration, European Medicines Company, Japanese Pharmaceuticals and Medical Tools Firm, or even Wellness Canada, 2010\u00e2 $ \"2020. Clin. Corrupt. Dis. 74, 1183\u00e2 $ \"1190 (2022 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPlanet Health Association. 2021 antibacterial brokers in professional and also preclinical development: an introduction and review. World Health Company https:\/\/www.who.int\/publications\/i\/item\/9789240047655 (27 May 2022). Prescription antibiotics: the business economics have to sustain the scientific research. Nature 625, 7 (2024 ). Thomas, D. &amp Wessel, C. The condition of advancement in antibacterial therapeutics. Medical Innovation Institution https:\/\/www.bio.org\/sites\/default\/files\/2022-02\/The-State-of-Innovation-in-Antibacterial-Therapeutics.pdf (February, 2022). Strich, J. et cetera. Examining specialist use of next-generation antibiotics against immune Gram-negative infections in U.S. medical centers: a retrospective accomplice research study. Ann. Intern. Medication. 177, 559\u00e2 $ \"572 (2024 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nThomas, D. &amp Wessel, C. The state of advancement in anti-bacterial therapies. Medical Technology Company https:\/\/www.bio.org\/sites\/default\/files\/2022-04\/BIO-Antibacterial-Report-2022.pdf (February 2022). Renwick, M. J., Brogan, D. M. &amp Mossialos, E. A methodical evaluation and important evaluation of incentive strategies for exploration and also progression of unique anti-biotics. J. Antibiot. 69, 73\u00e2 $ \"88 (2016 ). Article\u00c2.\nCAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nHealth And Wellness Emergency Preparedness and Action Authorization. Research and development of health care countermeasures. International Compensation https:\/\/health.ec.europa.eu\/health-emergency-preparedness-and-response-hera\/preparedness\/research-and-development-medical-countermeasures_en (2024 ). International Compensation. Pre-draft proposition for an European collaboration under Horizon Europe One Health Antimicrobial Protection. European Payment https:\/\/research-and-innovation.ec.europa.eu\/system\/files\/2022-02\/ec_rtd_he-partnerships-onehealth-amr.pdf (9 February 2022). Global Prescription Antibiotic R &amp D Collaboration. Entasis Therapeutics as well as the International Anti-biotic Research Study &amp Growth Partnership to build a brand new therapy for gonorrhea. GARDP https:\/\/gardp.org\/entasis-therapeutics-and-the-global-antibiotic-research-development-partnership-to-develop-a-new-treatment-for-gonorrhea\/ (6 July 2017). Atal, I., Trinquart, L., Porcher, R. &amp Ravaud, P. Differential globalization of sector- as well as non-industry-sponsored medical trials. PLoS ONE 10, e0145122 (2015 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nPlanet Health And Wellness Organization. Lot of professional trial registrations through area, condition, phase of growth, grow older and sexual activity of trial individuals (1999\u00e2 $ \"2022). Planet Health and wellness Institution https:\/\/www.who.int\/observatories\/global-observatory-on-health-research-and-development\/monitoring\/number-of-trial-registrations-by-year-location-disease-and-phase-of-development (February 2023). International Prescription Antibiotic Research and Development Collaboration. NeoSept1: a research study to find out the position of existing and brand new prescription antibiotics combos to address newborn babies that reside in hospital along with extreme sepsis. ISRCTN registry https:\/\/www.isrctn.com\/ISRCTN48721236 (17 January 2022). Hygienics Firm of Canada. Government of Canada brings in necessary assets to overcome antimicrobial resistance (AMR), Authorities of Canada https:\/\/www.canada.ca\/en\/public-health\/news\/2023\/05\/government-of-canada-makes-important-investment-to-fight-antimicrobial-resistance-amr.html (11 May 2023). International Anti-biotic Experimentation Alliance. Japan authorities funding supports GARDP\u00e2 $ s initiatives to resist antibiotic protection. GARDP https:\/\/gardp.org\/japan-government-funding-supports-gardps-efforts-to-counter-antibiotic-resistance\/ (19 October 2023). Novo Nordisk Base. Novo Nordisk Base companions along with CARB-X to combat drug-resistant diseases. novo nordisk foundation https:\/\/novonordiskfonden.dk\/en\/news\/novo-nordisk-foundation-partners-with-carb-x-to-fight-drug-resistant-infections\/ (9 January 2024). International Commission: European Health And Wellness as well as Digital Exec Company. Research on taking AMR medical countermeasures to the market. Publications Workplace of the European Union https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/51b2c82c-c21b-11ed-8912-01aa75ed71a1\/language-en (2023 ). Outterson, K. Estimating the ideal measurements of international pull motivations for anti-bacterial medications. Health and wellness Aff. 40, 1758\u00e2 $ \"1765 (2021 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nEvans, E. J., Meyer, A. &amp Conti, R. M. Dimension a market entrance incentive for the progression of brand new anti-biotics. Harvard Kennedy Institution https:\/\/www.hks.harvard.edu\/sites\/default\/files\/centers\/mrcbg\/Final_AWP_232.pdf (May 2024). Morel, C. M. et cetera. Field motivations and also antibiotic protection: an introduction to the antibiotic vulnerability perk. J. Antibiot. 73, 421\u00e2 $ \"428 (2020 ). CAS\u00c2.\n\nGoogle Scholar\u00c2.\nBonnifield, R. &amp Towse, A. An enthusiastic USG advanced devotion for subscription-based purchasing of unique antimicrobials and its own anticipated roi. Center for Global Progression https:\/\/www.cgdev.org\/publication\/ambitious-usg-advanced-commitment-subscription-based-purchasing-novel-antimicrobials (15 Nov 2022). Towse, A. &amp Silverman Bonnifield, R. G7 expenditures in brand-new prescription antibiotics will pay \u00e2 $\" for every person. Workplace of Health and wellness Economics https:\/\/www.ohe.org\/insight\/g7-investments-in-new-antibiotics-would-pay-off-for-everyone\/ (9 December 2022). NHS England. NHS boosts fight against serious diseases observing successful world-first pilot. NHS England https:\/\/www.england.nhs.uk\/2023\/07\/nhs-steps-up-battle-against-life-threatening-infections-following-successful-world-first-pilot\/ (11 July 2023). United States Our lawmakers. S. 1355 \u00e2 $\" PASTEUR Process of 2023. congress.gov www.congress.gov\/bill\/118th-congress\/senate-bill\/1355#:~:text=This%20bill%20authorizes%20the%20Department,and%20contains%20other%20related%20provisions (27 April 2023). European Payment. Reform of the EU pharmaceutical legalisation. European Payment https:\/\/health.ec.europa.eu\/medicinal-products\/pharmaceutical-strategy-europe\/reform-eu-pharmaceutical-legislation_en (26 April 2023). Gotham, D. et al. Reimbursement versions to attack market failings for antimicrobials: strategies consumed France, Germany, Sweden, the United Kingdom, and also the United States. Health and wellness Plan 125, 296\u00e2 $ \"306 (2020 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nInternational Alliance of Drug Manufacturers and Organizations. Coming from protection to durability: what could the future antibiotic pipeline look like? IFMPA https:\/\/www.ifpma.org\/publications\/from-resistance-to-resilience-what-could-the-future-antibiotic-pipeline-look-like\/ (14 May 2024). Worldwide AMR R&ampD Center &amp World Health Organization. Incentivising the development of brand new antibacterial procedures: 2023 report card due to the Worldwide AMR R&ampD Hub and also That. International AMR R&ampD Center https:\/\/globalamrhub.org\/publications\/incentivising-the-development-of-new-antibacterial-treatments-2023\/ (2023 ). Glover, R. E., Vocalist, A., Roberts, A. P. &amp Kirchhelle, C. Why is actually the UK membership model for antibiotics taken into consideration prosperous? Lancet Microbe 4, e852\u00e2 $ \"e853 (2023 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nNon-paper \u00e2 $\" novel stimuli for the development as well as continuing the market place of antimicrobials. Politician https:\/\/www.politico.eu\/wp-content\/uploads\/2022\/12\/01\/Non-paper-Transferable-exclusivity-voucher-for-AMR-2.pdf (2022 ). Liu, L. et al. Global, regional, as well as nationwide reasons for child death in 2000\u00e2 $ \"thirteen, along with projections to educate post-2015 priorities: an updated methodical analysis. Lancet 385, 430\u00e2 $ \"440 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nQuadri, F. et cetera. Antibacterial medicine scarcities from 2001 to 2013: effects for professional practice. Clin. Infect. Dis. 60, 1737\u00e2 $ \"1742 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nBenhabib, A. et al. The French coverage body for medicine shortages: description as well as trends coming from 2012 to 2018: an observational retrospective study. BMJ Open 10, e034033 (2020 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nKlein, E. Y. et al. Assessment of WHO antibiotic usage and also accessibility aim ats in 76 nations, 2000\u00e2 $ \"15: a review of pharmaceutical purchases records. Lancet Infect. Dis. 21, 107\u00e2 $ \"115 (2021 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPyzik, O. Z. &amp Abubakar, I. Battling the counterfeits: dealing with ineffective and falsified medicines. Nat. Rev. Dis. Guides 8, 55 (2022 ). Hayhoe, B., Greenfield, G. &amp Majeed, A. Is it receiving simpler to obtain prescription antibiotics in the UK? Br. J. Gen. Pract. 69, 54\u00e2 $ \"55 (2019 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nAfrican Community for Research Laboratory Medicine. Policy quick and infographics on antimicrobial resistance (AMR) in Africa. ASLM https:\/\/aslm.org\/resource\/policy-brief-and-infographics-on-antimicrobial-resistance-amr-in-africa\/ (14 September 2022). Kanu, J. S. et cetera. National antibiotic intake for individual usage in Sierra Leone (2017\u00e2 $ \"2019): a cross-sectional study. Trop. Medication. Affect. Dis. 6, 77 (2021 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nNamugambe, J. S. et al. National antimicrobial usage: study of central stockrooms products to in-patient care wellness amenities from 2017 to 2019 in Uganda. Trop. Medication. Affect. Dis. 6, 83 (2021 ).\nGoogle Scholar\u00c2.\nRobertson, J. et al. Varieties in the consumption of antimicrobial medicines in the European region, 2014\u00e2 $ \"2018: results and implications from ESAC-Net and also That Europe. Front. Pharmacol. 12, 639207 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nShukar, S. et al. Medicine scarcity: sources, impact, and reduction strategies. Front end. Pharmacol. 12, 693426 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nOutterson, K., Orubu, E. S. F., Rex, J., \u00c3 ... rdal, C. &amp Zaman, M. H. Patient accessibility in 14 high-income countries to brand-new antibacterials permitted by the US Fda, European Medicines Agency, Japanese Pharmaceuticals and also Medical Instruments Firm, or Wellness Canada, 2010\u00e2 $ \"2020. Clin. Affect. Dis. 74, 1183\u00e2 $ \"1190 (2021 ). Article\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nPulcini, C. et cetera. Lost antibiotics: a follow-up supply research in Europe, the U.S.A., Canada as well as Australia. Int. J. Antimicrob. Agents 49, 98\u00e2 $ \"101 (2017 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nRottingen, J. A. &amp Farrar, J. Targeted wellness advancement for worldwide health. Br. Med. J. 366, 15601 (2019 ).\nGoogle.com Scholar\u00c2.\nAMR Sector Collaboration. The 2023 AMR Field Collaboration development questionnaire: manufacturing and the atmosphere. amr Market Collaboration https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/12\/AMRIA_Manufacturing-and-the-environment-FINAL.pdf (2023 ). Munoz, V., Visentin, F., Foray, D. &amp Gaule, P. Can medical products be developed on a charitable manner? Discovering product advancement alliances for disregarded ailments. Sci. Public Policy 42, 315\u00e2 $ \"338 (2015 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nSwaminathan, S. et cetera. Restart biomedical R&ampD in the worldwide public passion. Nature 602, 207\u00e2 $ \"210 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nAfrica Centres for Ailment Management and also Prevention. Africa CDC initiates daring transfer to secure Africa\u00e2 $ s health future by producing a fifty billion dollar medical market. AfricaCDC https:\/\/africacdc.org\/news-item\/africa-cdc-spearheads-bold-move-to-secure-africas-health-future-by-creating-a-50-billion-dollar-medical-market\/ (19 February 2024). Blood, C., Morin, S., R\u00c3 \u00b8 ttingen, J. A. &amp Kieny, M. P. Arranging public-health trademark licensing deals to raise access to health and wellness technologies: an insider\u00e2 $ s tale. BMJ Chunk. Health 8, e012964 (2023 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nSuleman, F., Low, M., Moon, S. &amp Morgan, S. G. New business styles for research and development with price needs are needed to achieve fair prices of medications. Br. Medication. J. 368, l4408 (2020 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nCombating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator. Stewardship and access. CARB-X https:\/\/carb-x.org\/about\/stewardship-and-access\/ (2024 ). International Antibiotic R &amp D Collaboration. Shinogi, GARDP as well as CHAI declare landmark permit and also collaboration contracts to handle microbial diseases by increasing access to cefiderocol in 135 nations. GARDP https:\/\/gardp.org\/shionogi-gardp-and-chai-announce-landmark-license-and-collaboration-agreements-to-treat-bacterial-infections-by-expanding-access-to-cefiderocol-in-135-countries\/ (15 June 2022). AMR Sector Alliance. Leaving the lab: tracking the downtrend in AMR R&ampD specialists. amr Market Alliance https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/02\/Leaving-the-Lab_final-1.pdf (February, 2024). G7 Health And Wellness Ministers. G7 Wellness Ministers\u00e2 $ Communiqu\u00c3 \u00a9. G7 Germany www.g7germany.de\/resource\/blob\/974430\/2042058\/5651daa321517b089cdccfaffd1e37a1\/2022-05-20-g7-health-ministers-communique-data.pdf (twenty May 2022). G20. G20 phone call to action on antimicrobial protection. G7G20 Documents Data source https:\/\/g7g20-documents.org\/database\/document\/2022-g20-indonesia-sherpa-track-health-ministers-ministers-annex-g20-call-to-action-on-antimicrobial-resistance (28 Oct 2022). International Union on Aging &amp Contagious Illness Culture of United States. 2024 AMR preparedness mark report card. Evaluating federal government action on AMR policy. Worldwide Union on Aging https:\/\/globalcoalitiononaging.com\/wp-content\/uploads\/2024\/01\/2024-AMR-Index-Progress-Report.pdf (2024 ). Food and also Agriculture Company of the United Nations, United Nations Environment Programme, Planet Health Institution &amp. Planet Organisation for Creature Wellness. Worldwide data source for tracking antimicrobial protection (AMR): nation self-assessment study (TrACSS). That https:\/\/amrcountryprogress.org\/

/map-viewindicator2.3 (2023 ). Truck Katwyk, S. R. &amp Outterson K. Overview: AMR belongs in the as...

Integrating liver endpoints in scientific trials of cardio and kidney condition

.Attribute Medicine, Released online: 03 September 2024 doi:10.1038/ s41591-024-03223-zThis Viewpoin...